What characteristic is unique to the administration of Naloxegol compared to other opioid antagonists?

Naloxegol is distinct among opioid antagonists due to its formulation that prevents it from crossing the blood-brain barrier. This characteristic allows Naloxegol to effectively mitigate the side effects associated with opioid usage, such as constipation, without precipitating withdrawal symptoms or reversing analgesia in the central nervous system. By not entering the brain, Naloxegol specifically targets the peripheral opioid receptors located in the gastrointestinal tract. This mechanism makes it particularly useful in treating opioid-induced constipation without interfering with the pain-relieving effects of opioids used for chronic pain management.

The other characteristics associated with different forms of administration or functions of opioid antagonists do not apply to Naloxegol in the same way, reinforcing the uniqueness of its pharmacological profile.