What is a key adverse effect of Tramadol?

Tramadol is an atypical opioid analgesic that primarily works by binding to mu-opioid receptors and inhibiting the reuptake of norepinephrine and serotonin. A key concern when using Tramadol is its potential to reduce seizure threshold, which means that it can increase the risk of seizures, particularly in certain populations or when it is used in conjunction with other medications that also lower seizure thresholds. This effect is particularly notable in patients with a history of seizures, metabolic disorders, or those taking certain antidepressants or other drugs that can affect serotonin levels.

While other options such as sedation, constipation, and nausea can occur with Tramadol use, they are not as significant in terms of overall clinical concern compared to the risk of seizures. Hence, understanding the potential for reduced seizure threshold is crucial when prescribing Tramadol to ensure patient safety and to monitor for any signs of seizure activity.