Which opioid receptor is primarily located in the brain and spinal cord?

The mu opioid receptor is primarily located in the brain and spinal cord, making it a key player in the modulation of pain perception and the effectiveness of opioid analgesics. When activated, mu receptors play a significant role in producing analgesic effects, as they are involved in reducing the transmission of pain signals and also contribute to the emotional and reward pathways associated with pain relief.

Activation of mu receptors can lead to both the effective management of pain and the potential for various side effects, including euphoria and respiratory depression, which are important considerations in opioid prescribing and pain management. Thus, the center of action for many opioids, including morphine and fentanyl, is through the mu receptor, highlighting its primary location and function within the central nervous system.